Mabthera 500mg/50ml Solution for Infusion is an anticancer medicine that is used for the treatment of blood cancers.
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Rituximab:
Avoid consumption of alcohol while receiving Mabthera 500mg/50ml Solution as it may make you feel drowsier.
Not recommended for use in pregnant women unless necessary. Risks and benefits should be discussed with the doctor before using this medicine during pregnancy.
Not recommended for use in breastfeeding women unless necessary. Risks and benefits should be discussed with the doctor. The doctor may advise discontinuation of breastfeeding for a specific period or prescribe an alternative medicine based on the clinical condition.
Do not drive or operate any machines if your ability is affected by Mabthera 500mg/50ml Solution.
Mabthera 500mg/50ml Solution is considered probably safe to use in patients with kidney disease. Limited data suggest that dose adjustment may not be needed in these patients. It is advised to consult with the doctor regarding the use of the medicine in patients with kidney disease.
Limited information is available on the use of Mabthera 500mg/50ml Solution for Infusion for Infusion in patients with liver disease. Not recommended in patients with active liver disease or those who have viral hepatitis due to the risk of reactivating the infection. It is crucial to consult with the doctor regarding the use of the medicine in patients with liver disease.
Rituximab prevents the growth and spread of cancer cells in the body.
Non-Hodgkin's Lymphoma (NHL):
Chronic Lymphocytic Leukemia (CLL):
Rheumatoid Arthritis (RA):
Granulomatosis with Polyangiitis (GPA) and Microscopic Polyangiitis (MPA):
Rituximab is commonly used in the treatment of various conditions, including non-Hodgkin's lymphoma, chronic lymphocytic leukemia, rheumatoid arthritis, granulomatosis with polyangiitis, microscopic polyangiitis, and pemphigus vulgaris. Its mechanism of action involves targeting CD20-positive B-cells, leading to their destruction and modulation of the immune response.
Adult Dose:
Intravenous for Non-Hodgkin Lymphoma (NHL):
Chronic Lymphocytic Leukemia (CLL):
Rheumatoid Arthritis:
Child Dose:
Reconstitution:
Intravenous (IV) Administration:
First IV Infusion Rate:
Subsequent IV Infusions (90 minutes):
Interaction with Alcohol:
Interaction with Other Medicines:
Disease Interactions:
Autoimmune Disorders:
Cardiac Dysfunction:
Hepatitis B:
Tumor Lysis Syndrome:
Bone Marrow Suppression:
Renal Impairment:
Pregnancy Category C:
Definition: Animal reproduction studies have shown adverse effects on the fetus (teratogenic or embryotoxic, or other) and there are no controlled studies in women, or studies in women and animals are not available.
Use in Pregnancy: The drug should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Extensive Tumor Burden, Pulmonary Tumor Infiltration, or Pulmonary Insufficiency:
History of Cardiac Disease:
Effective Contraception:
Pregnancy:
Monitoring:
Premedication:
Monitoring for Infections:
Discontinuation in Case of Viral Hepatitis:
Lactation:
Store between 2-8° C.
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